A new research against Sloan Kettering memorial cancer points to a strong alternative to chemotherapy, surgery and radiation for some forms of cancer.
Almost 80% of patients suffering from various types of cancer were successfully treated with only immunotherapy, according to a new study published in the New England Journal of Medicine.
The immunotherapy protocol successfully treated 100% of patients with rectal cancer involved in the trial.
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“My husband, Tommy, and I prepared for the worst,” said Maureen Sideris, who was diagnosed with gastroesophageal junction cancer in 2022 and later participated in the trial.
Almost 80% of patients suffering from various types of cancer were successfully treated with only immunotherapy, going to the need for chemotherapy. (Istock)
“After being treated with only immunotherapy, I had no cancer tests and I did not have to undergo surgery, chemo or radiation,” he said in a MSK press release. “I felt like I won the lottery!”
Dr. Andrea Cercek, a gastrointestinal oncologist, oversaw the investigation along with the fellow Gastrointestinal Oncologist, Dr. Luiz Diaz.
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The couple intended to develop this approach in part due to the negative impacts of traditional treatment, according to launch.
The immunotherapy protocol successfully treated 100% of patients with rectal cancer involved in the trial. (Aaron Chown/Pa Images using Getty’s pictures)
“The use of the standard treatment of surgery, radiation and chemotherapy to treat rectal cancer is effective,” said Cercek.
“But treatments can leave infertile people and severely affect intestinal, urinary and sexual functions, as well as other aspects of everyday life.”
“After being treated with only immunotherapy, I had no cancer tests and I did not have to undergo surgery, chemo or radiation.”
The participants in the rehearsal were all patients with tumors ranging from stage 1 to stage 3, which means that tumors had not yet extended, said the release.
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The tumors also had a genetic mutation called the mismatch repair deficiency (MMRD), which makes them especially vulnerable to a type of immunotherapy called “control inhibitors”.
The inhibitors of the checkpoint, intravenously delivered to the participants, “unmask” the tumor cells, facilitating the body against the body against them. (Istock)
This therapy “develops” tumor cells, declared MSK, facilitating the patient’s own immune system recognizing and killing cancer cells.
The first clinical trial trying therapy began with only 18 patients, all of which had rectal cancer.
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“We knew there was a wide range of cancer types that had this same MMRD genetic mutation,” Cercek said. “We hoped that this approach could also help people who face these other cancers.”
In the extended trial, containing 103 patients, there were 49 patients with rectal cancer and 54 patients with other types of cancer. The participants received intravenous control inhibitory infusions for six months, according to the launch.
Thirty-five patients from 54 with different cancers of rectal cancer saw all the signs of their cancer disappear after immunotherapy. (Istock)
In the 49 patients with rectal cancer, there was no cancer evidence after immunotherapy.
Of the 54 patients with other cancers, 35 saw all the signs of cancer disappear after the therapy, according to a variety of tests performed for the study.
“This is a very significant answer and the results were even better than we expected,” Cercek said. “We found that some types of cancer responded well to immunotherapy, including colon and stomach cancer.”
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In 20% of non -rectal cancer patients who still needed surgery after therapy, researchers saw that immunotherapy often reduced the tumor and even lowered the stage classifications of some of the tumors, according to Cercek.
Timothy Yap, doctor, medical oncologist at the Center for Cancer of the University of Texas MD Anderson, agrees that the effectiveness of immunotherapy treatment for multiple types of cancer is “exciting”.
“Patients who respond can avoid the need for surgery, chemotherapy and radiation and benefit their quality of life,” said an oncologist. (Istock)
“We are always looking to improve the treatment strategies for cancer patients through innovative clinical trials, and this is no exception,” said Yap, who was not involved in the study, told Fox Digital.
“Patients who respond can avoid the need for surgery, chemotherapy and radiation and benefit their quality of life,” he said.
“This is a very significant answer and the results were even better than we expected.”
From the results of the original trial with rectal patients, the only immunotherapy approach has been incorporated into the treatment guidelines of the National Comprehensive Cancer Network, which is the group of doctor who establishes cancer treatments in the United States, declared the launch.
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Some of the original participants of the 2022 trial are still free of cancer today, several years after the initial treatment.
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