Toxin exposure increases the risk of colorectal cancer among younger adults

In the midst of the alarming tendency of cases of colorectal cancer that increases among young people, a new study has indicated a potential source.

Researchers at the University of California San Diego have linked a bacterial toxin called Colibactin to increased cases of early onset.

Cumped is produced by certain strains of Escherichia coli (E. coli) that exist in the colon and rectum, according to researchers.

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Exposure to bacterial toxin during early childhood can alter the DNA of colon cells so that it increases the risk of developing colorectal cancer before the age of 50, found the study.

The study, funded by Cancer Research UK, was published in Nature on April 23.

“ The key goal is that coribactin exposure is probably one of the main contributors to early early start colorectal cancer, ” Ludmil Alexandrov, a professor at the Shu Chien-Gene Bioengineering Department and the Molecular and Molecular Medicine Department of the UC San Diego, told Fox News Digital.

“They could have decades earlier than planned to develop colorectal cancer.”

In the study, researchers analyzed 981 colorectal cancer genomes of patients with early start colorectal cancer and late starts in 11 countries.

It was found that those who had a pre -coibactin exposure had specific mutations in their DNA, which have been shown to occur mainly in the first decade of life: “Putting children on an accelerated path to develop cancer as young adults.”

This group was 3.3 times more likely to develop a early start colorectal cancer compared to those that were diagnosed after 70 years.

It was found that these mutations represent 15% of early genetic alterations that increase the risk of colorectal cancer.

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“The cuminal signature was detected in more than 50% of the colorectal tumors of patients under 40, compared to less than 10% in tumors of senior individuals,” said Alexandrov.

“If anyone acquires one of these driver’s mutations when he is ten years old, he could have decades earlier than planned to develop a colorectal cancer, reaching -at the age of 40 instead of the 60’s,” said Alexandrov.

The fact that a microbial exhibition in the first years of life can leave a “lasting genomic imprint” and probably contribute to cancer in adulthood is “notable and protruding”, according to the researcher.

“It is a reminder that there are probably many other exhibitions that we have still discovered and that the way we encourage and protect children during these training years can have long -term implications for their lifelong health,” Fox News Digital told.

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“From my perspective, investing in the prevention of early life, healthy life and research is not only important, but is essential.”

Dr. Emil Lou, MD, PhD, an oncologist certified by the Board and Internal Medicine Physician at the University of Minnesota, agrees that the microbiome-“the constellation of microbes that includes bacteria that live in normal circumstances in our intestine”-it is a possible guilty of colorectal cancer of early onset.

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“It is less striking now that a decade ago that any form of bacteria, more specifically, a toxin derived from bacteria – could associate and potentially the main cause of cancer,” said Lou, who was not involved in the study, told Fox News Digital.

“What is especially derived is the long period of time that can cause the exposure to the bacteria in the first life and the time before the related cancer is diagnosed.”

Potential limitations

Alexandrov said that the study provides “strong genomic evidence” of a “amazing association” between coribactin and colorectal cancer of early appearance, but cannot demonstrate causation.

“Demonstrating unequivocal causality, demonstrating that coibactin is sufficient to start cancer in humans, it is still a major challenge,” Fox News Digital told.

“The definitive test of causality would require long -term prospective studies that begin early childhood to control microbial colonization and monitor cancer development for several decades.”

Lou agreed with this limitation, highlighting the complexity of cancer factors.

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“There are many aspects of our environment, both inside and outside our bodies, which can play a role in the development of cancer,” he said. “It is difficult to say or conclude whether a specific factor, in this case, toxin derived from bacteria-is true or even a significant cause of colorectal cancer.”

“Providing evidence of potential associations establish the foundations for more in -depth studies to determine if there is a truly cause and effect,” added Lou.

“If current trends continue, colorectal cancer is expected to become the main cause of cancer -related death among young adults by 2030.”

Alexandrov said that while findings are not yet justified in changes in screening or treatment guidelines, the “critical role of microbial exhibitions in early life is highlighted in terms of long -term cancer risk.

“We are actively working on the development of screening tests to detect the long -term effects of hacked exposure, with the aim of translating these findings into practical prevention strategies in the near future,” he added.

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Colorectal cancer cases have doubled among adults under the age of 50 for each of the last two decades, according to statistics.

“If current trends continue, colorectal cancer is expected to become the main cause of cancer -related death among young adults by 2030,” researchers concluded.